Serum IgE concentrations in neurological diseases.

Serum IgE levels were determined in 42 patients with Guillain Barre Syndrome and 22 patients with multiple sclerosis. Serum IgE concentrations were significantly elevated in about half of the patients with acute Guillain Barre Syndrome and tends to fall in patients with clinical improvement. Patients with multiple sclerosis and other acute and chronic central nervous system and peripheral system diseases have normal serum IgE levels. IgE is an important mediator of tissue damage in allergic diseases of immediate type and may also play an important role in acute Guillain Barre Syndrome.