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A new dihydrofolate reductase with low trimethoprim sensitivity induced by an R factor mediating high resistance to trimethoprim.

作者信息

Sköld O, Widh A

出版信息

J Biol Chem. 1974 Jul 10;249(13):4324-5.

PMID:4604016
Abstract
摘要

相似文献

1
A new dihydrofolate reductase with low trimethoprim sensitivity induced by an R factor mediating high resistance to trimethoprim.一种由介导对甲氧苄啶高度耐药的R因子诱导产生的、对甲氧苄啶敏感性低的新型二氢叶酸还原酶。
J Biol Chem. 1974 Jul 10;249(13):4324-5.
2
The purification and properties of the trimethoprim-resistant dihydrofolate reductase mediated by the R-factor, R388.由R因子R388介导的耐甲氧苄啶二氢叶酸还原酶的纯化及特性
Eur J Biochem. 1976 Jan 15;61(2):597-603. doi: 10.1111/j.1432-1033.1976.tb10055.x.
3
The binding of trimethoprim to bacterial dihydrofolate reductase.甲氧苄啶与细菌二氢叶酸还原酶的结合。
FEBS Lett. 1981 Apr 6;126(1):49-52. doi: 10.1016/0014-5793(81)81030-7.
4
Regulatory mutants of dihydrofolate reductase in Escherichia coli K12.大肠杆菌K12中二氢叶酸还原酶的调控突变体。
Mol Gen Genet. 1976 Aug 10;147(1):91-7. doi: 10.1007/BF00337941.
5
Site-directed mutagenesis of mouse dihydrofolate reductase. Mutants with increased resistance to methotrexate and trimethoprim.小鼠二氢叶酸还原酶的定点诱变。对甲氨蝶呤和甲氧苄啶耐药性增强的突变体。
J Biol Chem. 1988 Sep 5;263(25):12500-8.
6
Dihydrofolate reductase from trimethoprim-resistant Escherichia coli MB 3746 and MB 3747. Purification, amino acid composition, and some kinetic properties.
J Biol Chem. 1979 Mar 25;254(6):1799-805.
7
Plasmid-mediated trimethoprim-resistance in Staphylococcus aureus. Characterization of the first gram-positive plasmid dihydrofolate reductase (type S1).金黄色葡萄球菌中质粒介导的甲氧苄啶耐药性。首例革兰氏阳性质粒二氢叶酸还原酶（S1型）的特性分析。
Biochem J. 1987 Apr 1;243(1):309-12. doi: 10.1042/bj2430309.
8
Nucleotide sequence of dihydrofolate reductase genes from trimethoprim-resistant mutants of Escherichia coli. Evidence that dihydrofolate reductase interacts with another essential gene product.来自大肠杆菌甲氧苄啶抗性突变体的二氢叶酸还原酶基因的核苷酸序列。二氢叶酸还原酶与另一种必需基因产物相互作用的证据。
Mol Gen Genet. 1982;187(1):72-8. doi: 10.1007/BF00384386.
9
Increased substrate affinity in the Escherichia coli L28R dihydrofolate reductase mutant causes trimethoprim resistance.大肠杆菌 L28R 二氢叶酸还原酶突变体对底物亲和力的增加导致甲氧苄啶耐药性。
Phys Chem Chem Phys. 2017 May 10;19(18):11416-11428. doi: 10.1039/c7cp01458a.
10
Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.含有结合三甲氧苄氨嘧啶的大肠杆菌和鸡肝二氢叶酸还原酶的精细晶体结构。
J Biol Chem. 1985 Jan 10;260(1):381-91.

引用本文的文献

1
Trimethoprim resistance in surface and wastewater is mediated by contrasting variants of the dfrB gene.表面和废水中的甲氧苄啶耐药性是由 dfrB 基因的对比变异体介导的。
ISME J. 2023 Sep;17(9):1455-1466. doi: 10.1038/s41396-023-01460-7. Epub 2023 Jun 27.
2
Computational Development of Inhibitors of Plasmid-Borne Bacterial Dihydrofolate Reductase.质粒介导的细菌二氢叶酸还原酶抑制剂的计算研发
Antibiotics (Basel). 2022 Jun 7;11(6):779. doi: 10.3390/antibiotics11060779.
3
MgrB Inactivation Confers Trimethoprim Resistance in .MgrB失活赋予[具体对象]对甲氧苄啶的抗性 。 （原文此处信息不完整）
Front Microbiol. 2021 Jul 28;12:682205. doi: 10.3389/fmicb.2021.682205. eCollection 2021.
4
Mutational analysis confirms the presence of distal inhibitor-selectivity determining residues in B. stearothermophilus dihydrofolate reductase.突变分析证实了嗜热脂肪芽孢杆菌二氢叶酸还原酶中存在远端抑制剂选择性决定残基。
Arch Biochem Biophys. 2020 Oct 15;692:108545. doi: 10.1016/j.abb.2020.108545. Epub 2020 Aug 15.
5
Novel methylotrophy genes of Methylobacterium extorquens AM1 identified by using transposon mutagenesis including a putative dihydromethanopterin reductase.利用转座子诱变鉴定出的嗜甲基生丝微菌AM1的新型甲基营养基因，包括一种假定的二氢甲蝶呤还原酶。
J Bacteriol. 2003 Jan;185(2):669-73. doi: 10.1128/JB.185.2.669-673.2003.
6
High-level resistance to trimethoprim in clinical isolates of Campylobacter jejuni by acquisition of foreign genes (dfr1 and dfr9) expressing drug-insensitive dihydrofolate reductases.空肠弯曲菌临床分离株通过获得表达对药物不敏感的二氢叶酸还原酶的外源基因（dfr1和dfr9）而对甲氧苄啶产生高水平耐药。
Antimicrob Agents Chemother. 1998 Dec;42(12):3059-64. doi: 10.1128/AAC.42.12.3059.
7
A novel dihydrofolate reductase cassette inserted in an integron borne on a Tn21-like element.一个插入在类Tn21元件携带的整合子中的新型二氢叶酸还原酶盒。
Antimicrob Agents Chemother. 1993 Jun;37(6):1297-304. doi: 10.1128/AAC.37.6.1297.
8
Characterization of transposon Tn5086, carrying the site-specifically inserted gene dhfrVII mediating trimethoprim resistance.携带位点特异性插入基因dhfrVII介导甲氧苄啶抗性的转座子Tn5086的特性分析。
J Bacteriol. 1993 Mar;175(6):1796-805. doi: 10.1128/jb.175.6.1796-1805.1993.
9
Trimethoprim resistance in South African isolates of aerobic gram-negative faecal flora.南非需氧革兰氏阴性粪便菌群分离株对甲氧苄啶的耐药性
Eur J Clin Microbiol Infect Dis. 1993 Dec;12(12):916-21. doi: 10.1007/BF01992165.
10
Trimethoprim and sulfonamide resistance.甲氧苄啶和磺胺耐药性。
Antimicrob Agents Chemother. 1995 Feb;39(2):279-89. doi: 10.1128/AAC.39.2.279.