乳糜泻中针对小麦醇溶蛋白组分的循环抗体。

Circulating antibodies to wheat gliadin fractions in coeliac disease.

作者信息

Cornell H J

出版信息

Arch Dis Child. 1974 Jun;49(6):454-8. doi: 10.1136/adc.49.6.454.

DOI:10.1136/adc.49.6.454

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1648798/

Abstract

Titres of circulating antibodies to wheat gliadin fractions have been determined in children with active coeliac disease using a passive haemagglutination technique. The highest titres against fractions from S.E. Sephadex chromatography of a peptic-tryptic-pancreatic digest of gliadin were obtained against Fraction 9. Titres of serum antibodies in children with active coeliac disease against a peptictryptic digest of gliadin and its ultrafiltrate were significantly higher than those in children free from gastrointestinal disorders. Titres of sera from some asymptomatic sibs of the probands were abnormally high against the peptic-tryptic gliadin digest, suggesting a minor gut abnormality in these children, despite normal duodenal mucosal histology. Haemagglutination titres of sera from patients with active coeliac disease against the protein digests and fractions evaluated seemed to be related to the toxicity of these substances in this disease.

摘要

采用被动血凝技术测定了患有活动性乳糜泻的儿童体内针对小麦醇溶蛋白各组分的循环抗体滴度。针对醇溶蛋白的胃蛋白酶 - 胰蛋白酶 - 胰消化物经S.E.葡聚糖凝胶层析得到的组分，抗体滴度最高的是组分9。患有活动性乳糜泻的儿童针对醇溶蛋白的胃蛋白酶 - 胰蛋白酶消化物及其超滤物的血清抗体滴度显著高于无胃肠道疾病的儿童。先证者的一些无症状同胞的血清针对胃蛋白酶 - 胰蛋白酶醇溶蛋白消化物的滴度异常高，这表明尽管十二指肠黏膜组织学正常，但这些儿童存在轻微的肠道异常。患有活动性乳糜泻的患者血清针对所评估的蛋白消化物和组分的血凝滴度似乎与这些物质在该疾病中的毒性有关。

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