在AKR小鼠胚胎细胞中白血病病毒激活过程中存在稳定中间体的证据。
Evidence for a stable intermediate in leukemia virus activation in AKR mouse embryo cells.
作者信息
Ihle J N, Kenney F T, Tennant R W
出版信息
J Virol. 1974 Sep;14(3):451-6. doi: 10.1128/JVI.14.3.451-456.1974.
Abstract
Analysis of the requirement for serum in the activation of the endogenous leukemia virus expression in AKR mouse embryo cells by 5-iododeoxyuridine shows that activation can be dissociated into two discrete serum-dependent events. The first involves incorporation of 5-iododeoxyuridine into DNA and results in the formation of a stable "activation intermediate" resembling the provirus formed during infection of stationary mouse embryo cells with exogenous leukemia virus. The second event, resulting in expression of the activation intermediate as synthesis of virus proteins, requires DNA replication but not 5-iododeoxyuridine.
摘要
通过5-碘脱氧尿苷对AKR小鼠胚胎细胞内源性白血病病毒表达激活中血清需求的分析表明，激活可分为两个独立的血清依赖性事件。第一个事件涉及5-碘脱氧尿苷掺入DNA，并导致形成一种稳定的“激活中间体”，类似于静止小鼠胚胎细胞被外源性白血病病毒感染期间形成的前病毒。第二个事件导致激活中间体作为病毒蛋白合成而表达，需要DNA复制但不需要5-碘脱氧尿苷。
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