小鼠细胞中生物可区分的RNA C型病毒激活位点的独立分离。
Independent segregation of loci for activation of biologically distinguishable RNA C-type viruses in mouse cells.
作者信息
Aaronson S A, Stephenson J R
出版信息
Proc Natl Acad Sci U S A. 1973 Jul;70(7):2055-8. doi: 10.1073/pnas.70.7.2055.
Abstract
Two genetic loci for induction of RNA C-type virus in BALB/c mouse embryo cells segregate independently in backcross embryo cell lines. The viruses at these loci are shown to be biologically distinguishable. The first, described previously, codes for activation of a virus that grows preferentially in NIH Swiss embryo cells. The newly detected locus codes for activation of a virus that grows poorly, if at all, in NIH Swiss or BALB/c cells, but replicates well in a rat cell line. Its serologic properties are different from those of viruses of the two major serologic subgroups of murine leukemia virus. The present findings provide support for the hypothesis that the loci for virus induction in BALB/c cells represent genetic information for C-type viruses and that the endogenous viruses are subject to different cellular genetic controls.
摘要
在BALB/c小鼠胚胎细胞中诱导RNA C型病毒的两个基因位点，在回交胚胎细胞系中独立分离。这些位点的病毒在生物学上是可区分的。第一个位点（先前已描述）编码一种病毒的激活，该病毒优先在NIH瑞士小鼠胚胎细胞中生长。新检测到的位点编码一种病毒的激活，该病毒在NIH瑞士小鼠或BALB/c细胞中生长不佳（如果能生长的话），但在大鼠细胞系中复制良好。其血清学特性与小鼠白血病病毒两个主要血清学亚组的病毒不同。目前的研究结果支持这样的假设，即BALB/c细胞中病毒诱导的位点代表C型病毒的遗传信息，并且内源性病毒受到不同的细胞遗传控制。
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