支气管小细胞癌的治疗。
Treatment of small-cell carcinoma of bronchus.
作者信息
Laing A H, Berry R J, Newman C R, Smith P
出版信息
Lancet. 1975 Jan 18;1(7899):129-32. doi: 10.1016/s0140-6736(75)91428-2.
PMID:46049
Abstract
A randomised trial comparing radiotherapy with a multiple chemotherapy regimen in 68 patients with small cell carcinoma of bronchus is reported. Although overall survival was poor, radiotherapy resulted in significantly longer survival, better amelioration of symptoms, and less side-effects than chemotherapy. Patients achieving complete or partial remission on radiotherapy relapsed mainly with extrathoracic disease, in contradistinction to those treated with chemotherapy whose thoracic disease recurred.
摘要
报告了一项针对68例支气管小细胞癌患者的随机试验，比较了放疗与多药化疗方案的效果。尽管总体生存率较低，但放疗导致的生存期显著更长，症状改善更好，且副作用比化疗更少。放疗后达到完全或部分缓解的患者主要复发于胸外疾病，这与接受化疗的患者不同，后者的胸内疾病复发。
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