Wideroe T E, Vigander T
Br Med J. 1974 Jun 29;2(5921):699-701. doi: 10.1136/bmj.2.5921.699.
Beta-blocking drugs that prevent cranial vasodilatation are potentially valuable in the prophylaxis of migraine. Forty-nine patients with either classic or common migraine were treated with propranolol 160 mg/day for an average of six months. The first 30 of the patients to respond well to this treatment then participated in a double-blind cross-over trial with a placebo and propranolol. The mean frequency of headache attacks was significantly reduced by propranolol. None of the patients expressed a preference for placebo. Propranolol seems to be an effective prophylactic for common and classic migraine but the antimigraine properties of the various beta-blocking agents probably differ.
可预防颅血管扩张的β受体阻滞剂在偏头痛预防方面可能具有重要价值。49例典型或普通偏头痛患者接受了每日160毫克普萘洛尔治疗，平均治疗时间为6个月。最初对该治疗反应良好的30例患者随后参与了一项安慰剂与普萘洛尔的双盲交叉试验。普萘洛尔显著降低了头痛发作的平均频率。没有患者表示更喜欢安慰剂。普萘洛尔似乎是普通偏头痛和典型偏头痛的有效预防药物，但各种β受体阻滞剂的抗偏头痛特性可能有所不同。
