Laakso M L, Oja S S
Neurochem Res. 1979 Jun;4(3):411-23. doi: 10.1007/BF00963810.
Slices from rat cerebral cortex, brain stem, and cerebellum were incubated in media in which 1, 10, or 100 mmol/liter NaC1 had been replaced by equimolar amounts of LiC1. The initial influx of tryptophan and tyrosine into the slices diminished in the lithium-containing media. The lithium-induced inhibition was not competitive. The equilibrium accumulation of the amino acids was also less in the presence of LiC1. The incorporation of tryptophan and tyrosine into the proteins of the slices was inhibited by lithium. These were no clear differences between the brain areas studied. It has been suggested earlier that a lithium treatment enhances the in vivo cerebral uptake of these aromatic amino acids. The present results show that such a possible increase in uptake is not a direct effect of lithium ions on cell membranes.
将大鼠大脑皮层、脑干和小脑的切片置于培养基中培养，其中1、10或100 mmol/升的氯化钠已被等摩尔量的氯化锂替代。在含锂培养基中，色氨酸和酪氨酸向切片的初始流入量减少。锂诱导的抑制作用不是竞争性的。在氯化锂存在的情况下，氨基酸的平衡积累也较少。锂抑制了色氨酸和酪氨酸掺入切片蛋白质中。在所研究的脑区之间没有明显差异。早期曾有人提出，锂治疗可增强体内大脑对这些芳香族氨基酸的摄取。目前的结果表明，这种可能的摄取增加不是锂离子对细胞膜的直接作用。
