Lähdesmäki P, Hannus M L
Exp Brain Res. 1977 Dec 19;30(4):539-48. doi: 10.1007/BF00237643.
The influx of [3H]phenylalanine, [3H]tyrosine and [3H]tryptophan into brain cells was studied using brain slices from adult rats. Each aromatic amino acid inhibited the influx of the others into the brain cells. Tryptophan inhibited non-competitively the influx of phenylalanine, and phenylalanine similarly that of tyrosine and tryptophan. On the other hand, tyrosine inhibited competitively the influx of phenylalanine, and similarly tryptophan that of tyrosine, and tyrosine that of tryptophan. Among the aromatic organic acids tested, only phenylpyruvate and homogentisate had any inhibitory effect on the influx of the aromatic amino acids. These effects were generally competitive, non-competitive inhibition being obtained only in the inhibition of phenylalanine influx by homogentisate. The existence of only one common transport system for aromatic amino acids appear to be unlikely.
使用成年大鼠的脑切片研究了[3H]苯丙氨酸、[3H]酪氨酸和[3H]色氨酸进入脑细胞的情况。每种芳香族氨基酸都抑制其他氨基酸进入脑细胞。色氨酸非竞争性抑制苯丙氨酸进入脑细胞，苯丙氨酸同样抑制酪氨酸和色氨酸进入脑细胞。另一方面，酪氨酸竞争性抑制苯丙氨酸进入脑细胞，色氨酸同样抑制酪氨酸进入脑细胞，酪氨酸抑制色氨酸进入脑细胞。在所测试的芳香族有机酸中，只有苯丙酮酸和尿黑酸对芳香族氨基酸的进入有抑制作用。这些作用通常是竞争性的，只有尿黑酸抑制苯丙氨酸进入时获得非竞争性抑制。似乎不太可能存在仅一个芳香族氨基酸的共同转运系统。
