乡村城镇中的神经管缺陷。特定小区域内聚集现象的证实。
Neural tube defects in a country town. Conformation of clustering within a particularly small area.
作者信息
Aylett M J, Roberts C J, Lloyd S
出版信息
Br J Prev Soc Med. 1974 Aug;28(3):177-9. doi: 10.1136/jech.28.3.177.
Abstract
Eighteen infants with neural tube defects occurring in 979 births over five years in a small Wiltshire town were investigated for evidence of spatial epidemicity. Applying a method not used previously in the study of these defects, clustering was confirmed, a critical distance between cases of up to 100 metres giving a highly significant result (P = 0·001), and with one exception the observed number of pairs significantly exceeds the expected number (P < 0·01) even up to 1,000 metres.
摘要
在威尔特郡一个小镇的五年间，979例出生婴儿中有18例患有神经管缺陷，对这些病例进行了空间流行性证据调查。采用一种此前未用于此类缺陷研究的方法，证实了病例聚集现象，病例之间高达100米的临界距离得出了高度显著的结果（P = 0·001），并且除了一个例外，即使距离达到1000米，观察到的病例对数量也显著超过预期数量（P < 0·01）。
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