脊柱裂易感性：探寻与母体胃酸分泌的关系。
Predisposition to spina bifida: Search for a relation to maternal gastric acid secretion.
作者信息
Stanway P A, Samloff I M, Brace C J, Renwick J H
出版信息
J Med Genet. 1977 Oct;14(5):332-4. doi: 10.1136/jmg.14.5.332.
Abstract
The peak acid output of the stomach in a group of 71 mothers of spina bifida children and in 71 matched controls was estimated indirectly by the serum level of group I pepsinogens. The mean levels did not differ significantly, suggesting that the conjectured teratogen is not specially acid-labile. The variance was significantly higher in index subjects than in controls, but the interpretation of this finding is not clear.
摘要
通过I组胃蛋白酶原的血清水平间接估计了71名脊柱裂患儿母亲和71名匹配对照者的胃最大酸分泌量。平均水平没有显著差异，这表明推测的致畸原并非特别酸不稳定。研究对象的方差显著高于对照组，但这一发现的解释尚不清楚。
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