Quinazolines. 12. 1,3-Diaminobenzo(f)quinazolines containing long-chain alkyl or chloro substituents on the central ring. Synthesis and biological evaluation as candidate antifolate and antimalarial agents.
作者信息
Rosowsky A, Huang P C, Papathanasopoulos N, Modest E J
出版信息
J Med Chem. 1974 Nov;17(11):1217-22. doi: 10.1021/jm00257a016.
PMID:4606974
Abstract
摘要
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Quinazolines. 12. 1,3-Diaminobenzo(f)quinazolines containing long-chain alkyl or chloro substituents on the central ring. Synthesis and biological evaluation as candidate antifolate and antimalarial agents.喹唑啉类。12. 中心环上含有长链烷基或氯取代基的1,3 - 二氨基苯并(f)喹唑啉。作为候选抗叶酸和抗疟药的合成及生物学评价。
J Med Chem. 1974 Nov;17(11):1217-22. doi: 10.1021/jm00257a016.
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Synthesis and evaluation of 6-arylactamido-2,4-diaminoquinazolines and related compounds as folic acid antagonists.
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Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects.叶酸拮抗剂。13. 2,4 - 二氨基 - 6 - [（α,α,α - 三氟 - 间甲苯基）硫代]喹唑啉及相关的2,4 - 二氨基 - 6 - [（苯基和萘基）硫代]喹唑啉，一类具有非凡抗疟和抗菌作用的独特抗代谢物。
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