Folate antagonists. 9. 2,4-Diamino-6-((aralkyl)alkylamino)quinazolines, a potent class of antimetabolites with prodigious antimalarial effects.

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作者信息

Elslager E F, Bird O D, Clarke J, Perricone S C, Worth D F

出版信息

J Med Chem. 1972 Nov;15(11):1138-46. doi: 10.1021/jm00281a012.

DOI:10.1021/jm00281a012

PMID:4631920

Abstract

摘要

相似文献

Folate antagonists. 9. 2,4-Diamino-6-((aralkyl)alkylamino)quinazolines, a potent class of antimetabolites with prodigious antimalarial effects.

J Med Chem. 1972 Nov;15(11):1138-46. doi: 10.1021/jm00281a012.

Folate antagonists. 3. 2,4-Diamino-6-(heterocyclic)quinazolines, a novel class of antimetabolites with potent antimalarial and antibacterial activity.

J Med Chem. 1972 Aug;15(8):827-36. doi: 10.1021/jm00278a008.

Folate antagonists. 2. 2,4-Diamino-6-((aralkyl and (heterocyclic)methyl)amino)quinazolines, a novel class of antimetabolites of interest in drug-resistant malaria and Chagas' disease.

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Folate antagonists. 12. Antimalarial and antibacterial effects of 2,4-diamino-6-[(aralkyl and alicyclid)thio-, sulfinyl-, and sulfonyl]quinazolines.

J Med Chem. 1978 Jul;21(7):639-43. doi: 10.1021/jm00205a009.

Folate antagonists. 13. 2,4-Diamino-6-](alpha,alpha,alpha-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects.叶酸拮抗剂。13. 2,4 - 二氨基 - 6 - [（α,α,α - 三氟 - 间甲苯基）硫代]喹唑啉及相关的2,4 - 二氨基 - 6 - [（苯基和萘基）硫代]喹唑啉，一类具有非凡抗疟和抗菌作用的独特抗代谢物。

J Med Chem. 1978 Oct;21(10):1059-70. doi: 10.1021/jm00208a010.

2,4-Diaminothieno(2,3-d)pyrimidines as antifolates and antimalarials. 2. Synthesis of 2,4-diaminopyrido(4',3':4,5)thieno(2,3-d)pyrimidines and 2,4-diamino-8H-thiopyrano(4',3':4,5)thieno(2,3-d)pyrimidines.

J Med Chem. 1973 Mar;16(3):188-91. doi: 10.1021/jm00261a003.

Quinazolines. 12. 1,3-Diaminobenzo(f)quinazolines containing long-chain alkyl or chloro substituents on the central ring. Synthesis and biological evaluation as candidate antifolate and antimalarial agents.喹唑啉类。12. 中心环上含有长链烷基或氯取代基的1,3 - 二氨基苯并(f)喹唑啉。作为候选抗叶酸和抗疟药的合成及生物学评价。

J Med Chem. 1974 Nov;17(11):1217-22. doi: 10.1021/jm00257a016.

Folate antagonists. 4. Antimalarial and antimetabolite effects of 2,4-diamino-6-((benzyl)amino)pyrido(2,3-d)-pyrimidines.叶酸拮抗剂。4. 2,4-二氨基-6-（苄基）氨基吡啶并[2,3-d]嘧啶的抗疟和抗代谢作用。

J Med Chem. 1972 Aug;15(8):837-9. doi: 10.1021/jm00278a009.

2,4-Diaminothieno(2,3-d)pyrimidines as antifolates and antimalarials. 1. Synthesis of 2,4-diamino-5,6,7,8-tetrahydrothianaphthena(2,3-d)pyrimidines and related compounds.

J Med Chem. 1973 Mar;16(3):185-8. doi: 10.1021/jm00261a002.

2,4-Diaminothieno(2,3-d)pyrimidines as antifolates and antimalarials. 3. Synthesis of 5,6-disubstituted derivatives and related tetracyclic analogs.

J Med Chem. 1973 Mar;16(3):191-4. doi: 10.1021/jm00261a004.

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