Ezoe H, Mak S
J Virol. 1974 Oct;14(4):733-9. doi: 10.1128/JVI.14.4.733-739.1974.
Physical and biological properties of highly oncogenic human adenovirus type 12 were compared with a low oncogenic mutant (cyt mutant). Parental and cyt mutant virions had very similar density and DNA size. However, the parental strain virion preparations contained a much higher proportion of defective virions (capable of cell killing, but not able to induce T- or V-antigen) than cyt mutant stock. It was also found that cyt mutant had a reduced virus yield in several human cell lines compared with the parental strain.
将高致癌性的人12型腺病毒的物理和生物学特性与低致癌性突变体（cyt突变体）进行了比较。亲代病毒和cyt突变体病毒粒子具有非常相似的密度和DNA大小。然而，亲代毒株的病毒粒子制剂中含有缺陷病毒粒子（能够杀死细胞，但不能诱导T抗原或V抗原）的比例比cyt突变体毒株高得多。还发现，与亲代毒株相比，cyt突变体在几种人类细胞系中的病毒产量有所降低。
