Barnett L B, Schwartz E
J Neurol Neurosurg Psychiatry. 1974 Aug;37(8):966-70. doi: 10.1136/jnnp.37.8.966.
A case is reported of a 34 year old white male with chronic renal failure secondary to glomerulonephritis who received four renal transplants over a period of five years. He died 25 months after the fourth transplant. Necropsy revealed a reticulum cell sarcoma-microglioma of the brain. The possibility that multiple transplants may have had a synergistic effect in the development of a malignant cerebral lymphoma in this patient is briefly discussed in the light of the current theories concerning the pathogenesis of the tumours in transplant recipients and in the context of the present therapeutic approach to graft rejection.
报告了一例34岁的白人男性病例，该患者因肾小球肾炎继发慢性肾衰竭，在五年内接受了四次肾移植。他在第四次移植后25个月死亡。尸检发现脑部有网状细胞肉瘤 - 微胶质瘤。根据目前关于移植受者肿瘤发病机制的理论，并结合当前对移植排斥的治疗方法，简要讨论了多次移植可能对该患者恶性脑淋巴瘤的发生具有协同作用的可能性。
