慢性同种异体疾病。II. 淋巴瘤的发展。
Chronic allogeneic disease. II. Development of lymphomas.
作者信息
Armstrong M Y, Gleichmann E, Gleichmann H, Beldotti L, Andre-Schwartz J, Schwartz R S
出版信息
J Exp Med. 1970 Sep 1;132(3):417-39. doi: 10.1084/jem.132.3.417.
Abstract
The incidence of lymphomas in 371 CAF(1) mice injected with BALB/c spleen cells was compared with that in 324 control CAF(1) mice. A high incidence of lymphomas was found in the treated mice, but not in the control animals. The development of the neoplasms was a function of the number of parental cells administered. Analyses of the injected mice for the presence of donor cells indicated that the majority of the injected parental cells lost antihost activity, probably within 24 hr of their administration. The tumors were of host origin, as judged by transplantation tests and antigenic analysis of tumor cells.
摘要
将注射了BALB/c脾细胞的371只CAF(1)小鼠的淋巴瘤发病率与324只对照CAF(1)小鼠的发病率进行了比较。在经处理的小鼠中发现淋巴瘤的高发病率，但在对照动物中未发现。肿瘤的发生是所给予亲代细胞数量的函数。对注射小鼠进行供体细胞存在情况的分析表明，大多数注射的亲代细胞可能在给药后24小时内失去了抗宿主活性。通过移植试验和肿瘤细胞的抗原分析判断，肿瘤起源于宿主。
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