Barrie W W, Wood E H, Crumlish P, Forbes C D, Prentice C R
Br Med J. 1974 Oct 19;4(5937):130-3. doi: 10.1136/bmj.4.5937.130.
The effect of a low-dosage regimen of ancrod in the prevention of postoperative deep vein thrombosis was assessed in 24 patients having surgical repair of fractured neck femur and compared with 25 control patients who did not receive therapy. The objective of the therapy was to lower the preoperative fibrinogen level and produce a low concentration of fibrin degradation products yet avoid the haemorrhagic complications of total defibrination. Ancrod therapy proved feasible to carry out, was not associated with haemorrhagic complications, and produced sustained, predictable reductions in fibrinogen concentration. There were seven thromboembolic complications in the control patients compared to one such complication in the ancrod-treated patients. Five deaths occurred in the control group and one in the treated group. Though the incidence of deep vein thrombosis was not apparently affected by ancrod it appeared on venography that the thrombi in the treated patients were less extensive than those in the control patients. Finally, some discrepancies in the diagnosis of deep vein thrombosis by the three techniques of clinical examination, (125)I-fibrinogen scanning, and ascending venography were identified.
对24例接受股骨颈骨折手术修复的患者评估了低剂量安克洛德方案预防术后深静脉血栓形成的效果，并与25例未接受治疗的对照患者进行了比较。该治疗的目的是降低术前纤维蛋白原水平并产生低浓度的纤维蛋白降解产物，同时避免完全去纤维蛋白化的出血并发症。安克洛德治疗被证明可行，未出现出血并发症，并使纤维蛋白原浓度持续、可预测地降低。对照患者中有7例发生血栓栓塞并发症，而接受安克洛德治疗的患者中只有1例。对照组有5例死亡，治疗组有1例死亡。虽然深静脉血栓形成的发生率似乎未受安克洛德影响，但静脉造影显示，治疗患者的血栓比对照患者的血栓范围小。最后，确定了临床检查、（125）I-纤维蛋白原扫描和上行静脉造影这三种技术在深静脉血栓形成诊断中的一些差异。
