内毒素耐受性以及小鼠对都柏林沙门氏菌和无乳链球菌感染的非特异性抗性诱导
Endotoxin tolerance and the induction of nonspecific resistance to Salmonella dublin and Streptococcus agalactiae infections in mice.
作者信息
Hill A W, Hibbitt K G, Shears A
出版信息
Br J Exp Pathol. 1974 Jun;55(3):269-74.
Abstract
Data are presented in this paper which show that endotoxin stimulated nonspecific resistance of mice to bacterial infections is not lost when the animals become tolerant to endotoxin and in some cases can be increased as the animals become more tolerant to endotoxin. Experiments are also presented which suggest that the specific antibodies to endotoxin that develop in the serum of tolerant animals may be unimportant in the development of the tolerance or in the enhancement of the nonspecific resistance.
摘要
本文所呈现的数据表明，当动物对内毒素产生耐受时，内毒素刺激的小鼠对细菌感染的非特异性抵抗力不会丧失，并且在某些情况下，随着动物对内毒素的耐受性增强，这种抵抗力还会增加。文中还展示了一些实验，这些实验表明，耐受动物血清中产生的内毒素特异性抗体，在耐受性的形成或非特异性抵抗力的增强过程中可能并不重要。
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