Hill A W, Hibbitt K G, Shears A
Br J Exp Pathol. 1974 Apr;55(2):194-202.
The nonspecific resistance of mice to challenge was enhanced following the administration of an O55 B5 endotoxin. Although the route of administration of the endotoxin and the challenge organism were varied, the nonspecific resistance of the animal was enhanced in all the experiments. The efficiency of this resistance was highest when the inducing substance and the challenge dose of bacteria were administered intraperitoneally. Poly I: C and double stranded RNA were also studied but were much less effective than endotoxin in stimulating a resistance to infection. Stimulation of the fixed macrophages could not explain fully the enhanced resistance, since the clearance rates of colloidal carbon and radioactively labelled bacteria from the blood were not significantly enhanced after the administration of endotoxin. Furthermore, splenectomized animals, and animals injected with agents which interfere with the RES activity, trypan blue and corticosteroids, still developed a degree of nonspecific resistance to infection.
给予O55 B5内毒素后，小鼠对攻击的非特异性抵抗力增强。尽管内毒素的给药途径和攻击微生物有所不同，但在所有实验中动物的非特异性抵抗力均增强。当诱导物质和细菌攻击剂量经腹腔注射时，这种抵抗力的效率最高。还研究了聚肌苷酸:胞苷酸（Poly I:C）和双链RNA，但它们在刺激抗感染能力方面比内毒素的效果要差得多。固定巨噬细胞的刺激并不能完全解释抵抗力的增强，因为给予内毒素后，血液中胶体碳和放射性标记细菌的清除率并未显著提高。此外，脾切除的动物以及注射了干扰网状内皮系统（RES）活性的试剂（台盼蓝和皮质类固醇）的动物，仍然对感染产生了一定程度的非特异性抵抗力。
