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1
Plaque-forming cells in rabbits following stimulation of the appendix with sheep erythrocytes.用绵羊红细胞刺激兔阑尾后产生的空斑形成细胞。
Immunology. 1974 Aug;27(2):305-10.
2
Rate of hemolytic antibody production by single cells in vivo in rabbits.兔体内单细胞产生溶血抗体的速率。
J Immunol. 1974 Jan;112(1):17-25.
3
Appendix and M antibody formation. V. Appendix and thymus cell synergism in the direct and indirect plaque-forming cell responses to sheep erythrocytes in the rabbit.阑尾与M抗体形成。V. 兔对绵羊红细胞的直接和间接空斑形成细胞反应中阑尾与胸腺细胞的协同作用。
J Immunol. 1972 Aug;109(2):410-2.
4
Antibody-forming cells in the thymus of guinea pigs after intrathymic injection of sheep erythrocytes.豚鼠胸腺内注射绵羊红细胞后胸腺中的抗体形成细胞
Ann Med Exp Biol Fenn. 1971;49(4):176-9.
5
The immune response to sheep erythrocytes in the lizard Calotes versicolor.变色树蜥对绵羊红细胞的免疫反应。
J Immunol. 1972 Sep;109(3):415-9.
6
Selective inhibition of plaque-forming cells by bursa-specific antisera.法氏囊特异性抗血清对斑块形成细胞的选择性抑制作用。
J Immunol. 1971 May;106(5):1416-7.
7
Decline in suppressor T cell function with age in female NZB mice.雌性新西兰黑小鼠随着年龄增长抑制性T细胞功能下降。
J Immunol. 1974 Jan;112(1):9-16.
8
Alternative potentiating and inhibitory effects of GVH reaction on formation of antibodies against a thymus-independent polysaccharide (S3).移植物抗宿主反应对针对非胸腺依赖性多糖（S3）抗体形成的替代增强和抑制作用。
J Immunol. 1973 Jul;111(1):72-84.
9
Requirement for continuous antigenic stimulation in the development and differentiation of antibody-forming cells: effect of antigen dose.抗体形成细胞发育和分化过程中对抗持续抗原刺激的需求：抗原剂量的影响
Immunology. 1971 May;20(5):707-18.
10
Antibody production by host cells in x-irradiated recipients of allogeneic spleen cells.在接受异体脾细胞X射线照射的受体中宿主细胞产生抗体的情况。
J Immunol. 1970 Oct;105(4):957-63.

本文引用的文献

1
THE DEVELOPMENTAL BIOLOGY OF LYMPHOID TISSUE IN THE RABBIT. CONSIDERATION OF THE ROLE OF THYMUS AND APPENDIX.家兔淋巴组织的发育生物学。胸腺和阑尾作用的探讨。
Lab Invest. 1964 Mar;13:259-71.
2
Changes in subcellular and circulating antibody levels during the hemolysin response in rabbits.兔子溶血素反应过程中亚细胞及循环抗体水平的变化
J Immunol. 1967 Apr;98(4):860-7.
3
Migration of antibody-forming cells and antigen-sensitive precursors between spleen, thymus and bone marrow.抗体形成细胞和抗原敏感前体细胞在脾脏、胸腺和骨髓之间的迁移。
Immunology. 1968 Apr;14(4):553-61.
4
Restoration of antibody response to sheep erythrocytes in thymectomized mice following grafting of rabbit appendix.在胸腺切除的小鼠移植兔阑尾后，对绵羊红细胞的抗体反应恢复。
Proc Soc Exp Biol Med. 1971 May;137(1):82-6. doi: 10.3181/00379727-137-35517.
5
Appendix and gamma-M antibody formation. IV. Synergism of appendix and bone marrow cells in early antibody response to sheep erythrocytes.阑尾与γ-M抗体形成。IV. 阑尾细胞与骨髓细胞在对绵羊红细胞早期抗体反应中的协同作用。
J Immunol. 1970 Sep;105(3):791-2.
6
Appendix and gamma M-antibody formation. I. Immune response and tolerance to bovine gamma globulin in irradiated, appendix-shielded rabbits.阑尾与γM抗体形成。I. 经辐射且阑尾受保护的兔子对牛γ球蛋白的免疫反应与耐受性
J Immunol. 1970 Mar;104(3):616-25.
7
Lymphoepithelial tissues of the intestine and differentiation of antibody production.肠道的淋巴上皮组织与抗体产生的分化
Science. 1968 Jul 19;161(3838):265-6. doi: 10.1126/science.161.3838.265.
8
A mammalian equivalent of the avian bursa of Fabricius.
Lancet. 1966 Jun 25;1(7452):1388-91. doi: 10.1016/s0140-6736(66)90300-x.

用绵羊红细胞刺激兔阑尾后产生的空斑形成细胞。

Plaque-forming cells in rabbits following stimulation of the appendix with sheep erythrocytes.

作者信息

Sussdorf D H

出版信息

Immunology. 1974 Aug;27(2):305-10.

PMID:4609296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445556/
Abstract

Sheep erythrocyte (SRBC) antigen was delivered directly into the lymphoid component of the appendix or via the appendicular artery, followed by ligation or clamping of appendicular vessels. Antigen was also injected intravenously, into the spleen, or into the thymus. Counts of anti-SRBC plaque-forming cells (PFC) in the appendix were compared with counts in the spleen and thymus. None of the injection routes employed resulted in an elevation of PFC activity above background in the appendix. However, delivery of antigen via the appendicular artery caused a marked increase of PFC activity in the spleen. These results and other available evidence point towards a helper-cell function of lymphocytes in the appendix, and therefore suggest a central role of this organ in humoral immunity.

摘要

绵羊红细胞（SRBC）抗原通过直接注入阑尾的淋巴组织或经阑尾动脉注入，随后结扎或钳夹阑尾血管。抗原也通过静脉注射、注入脾脏或胸腺。将阑尾中抗SRBC斑块形成细胞（PFC）的计数与脾脏和胸腺中的计数进行比较。所采用的任何注射途径均未导致阑尾中PFC活性升高至背景水平以上。然而，经阑尾动脉递送抗原导致脾脏中PFC活性显著增加。这些结果和其他现有证据表明阑尾中的淋巴细胞具有辅助细胞功能，因此提示该器官在体液免疫中起核心作用。