Perey D Y, Cooper M D, Good R A
Science. 1968 Jul 19;161(3838):265-6. doi: 10.1126/science.161.3838.265.
The antibody response of young rabbits to the injection of killed Brucella abortus was abolished by prior extirpation of intestinal lymphoepithelial tissues combined with lethal xirradiation and reconstitution with rabbit fetal liver cells. Extirpative surgery alone, like lethal x-irradiation and reconstitution without surgery, did not abolish this response. Intestinal lymphoepithelial tissues of rabbits apparently play a central lymphoid function and are responsible for the differentiation of the lymphoid cell line which produces specific antibody and immunoglobulins.
幼兔对注射灭活布鲁氏菌流产菌的抗体反应，在事先切除肠道淋巴上皮组织并结合致死性X射线照射，然后用兔胎儿肝细胞进行重建后消失。单独的切除手术，如致死性X射线照射以及未进行手术的重建，并未消除这种反应。兔的肠道淋巴上皮组织显然发挥着中枢淋巴功能，并且负责产生特异性抗体和免疫球蛋白的淋巴细胞系的分化。
