慢性抗惊厥治疗导致的肾脏对速尿不敏感。
Renal insensitivity to frusemide caused by chronic anticonvulsant therapy.
作者信息
Ahmad S
出版信息
Br Med J. 1974 Sep 14;3(5932):657-9. doi: 10.1136/bmj.3.5932.657.
Abstract
The diuretic response to 20-mg and 40-mg oral doses of frusemide was significantly smaller in a group of epileptic patients on chronic anticonvulsant therapy than in a group of normal staff members. Furthermore, the peak response was considerably delayed in the epileptic patients. The difference in the volume of diuresis was maintained after intravenous injection of 20 mg of frusemide. It is suggested that the sensitivity of the renal tubule to the diuretic action of frusemide is reduced by anticonvulsant therapy and that there may also be delayed absorption of the drug from the gastrointestinal tract.
摘要
在一组接受慢性抗惊厥治疗的癫痫患者中，口服20毫克和40毫克速尿的利尿反应明显小于一组正常工作人员。此外，癫痫患者的峰值反应明显延迟。静脉注射20毫克速尿后，利尿量的差异仍然存在。提示抗惊厥治疗会降低肾小管对速尿利尿作用的敏感性，并且药物从胃肠道的吸收可能也会延迟。
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