Wilson M R, Hohmann A W
Infect Immun. 1974 Oct;10(4):776-82. doi: 10.1128/iai.10.4.776-782.1974.
A method was developed to test for the ability of Escherichia coli to adhere to isolated intestinal epithelial cells. Of the E. coli tested, those having either K88ac or K88ab antigens adhered to the cells, and those which did not have these antigens did not. Since some enteropathogenic E. coli did not have the ability to adhere, it is assumed that adherence is not an essential factor of pathogenesis but rather should be considered an enhancement to the pathogenicity of some E. coli. None of the E. coli enteropathogens of cattle tested adhered to either pig or cattle cells. Similarly, human strains did not adhere to pig cells. Although the test system may not have been ideal for human or bovine E. coli, the results reported here suggest that adhesiveness is a property limited to porcine enteropathogenic E. coli carrying one of the K88 antigens. Adhesiveness is associated with the K88c or K88b antigens, and their adhesive ability is only neutralizable by the homologous antisera.
开发了一种方法来测试大肠杆菌黏附分离的肠上皮细胞的能力。在所测试的大肠杆菌中，具有K88ac或K88ab抗原的菌株能够黏附到细胞上，而没有这些抗原的菌株则不能。由于一些肠道致病性大肠杆菌没有黏附能力，因此推测黏附不是发病机制的必要因素，而应被视为某些大肠杆菌致病性的增强因素。所测试的牛源大肠杆菌肠道病原菌均未黏附到猪或牛的细胞上。同样，人源菌株也未黏附到猪细胞上。尽管该测试系统可能对人源或牛源大肠杆菌并不理想，但此处报道的结果表明，黏附性是携带K88抗原之一的猪肠道致病性大肠杆菌所特有的特性。黏附性与K88c或K88b抗原相关，并且它们的黏附能力仅可被同源抗血清中和。
