Tillement J P, Houin G, Lhoste F, d'Athis P, Lartigue C, Rapin M
Nouv Presse Med. 1979 May 26;8(23):1911-4.
Nalidixic acid is effective toward Gram negative infections but its short half-life and potential neurological toxicity explain that its parenteral use is hazardous. Interindividual variations of its pharmacokinetic parameters explain also the absolute necessity of a careful drug monitoring adapted to each patient. The study of plasma kinetics of a single dose of nalidixic acid injected by intravenous route, shows these metabolic variations. With this results, the predicted plasma drug concentrations show that classical dosage regimens are adapted only to a little number of patients. Advantages and inadequacies of a single daily intravenous infusion of nalidixic acid are next analysed.
萘啶酸对革兰氏阴性菌感染有效，但其半衰期短和潜在的神经毒性表明其肠胃外给药具有危险性。其药代动力学参数的个体差异也说明了针对每个患者进行仔细药物监测的绝对必要性。对静脉注射单剂量萘啶酸的血浆动力学研究显示了这些代谢差异。基于这些结果，预测的血浆药物浓度表明经典给药方案仅适用于少数患者。接下来分析了每日一次静脉输注萘啶酸的优缺点。
