[Pharmacokinetics, tolerance and therapeutic effect of trimethoprim-sulfametrol-infusions (author's transl)].

Lidaprim was administered as infusion to 6 healthy volunteers for 10 days in an interval of 12 hours for calculation of the pharmacokinetic parameters. Furthermore 31 patients with various severe infectious diseases were treated for 5-27 days with 2 or 3 infusions daily. Local tolerance was excellent. Side effects were observed only in 1 patient, who developed a rash. The cumulation equilibrium is reached for trimethoprim and also for total and free sulfonamide on the 3rd day. The clinical results were excellent: 22 of the 31 patients with severe infectious diseases could be cured.