Clarke J, Passa P, Canivet J
Nouv Presse Med. 1979 Feb 10;8(7):513-7.
HbA1c is the product of a slow, virtually irreversible reaction, occurring continuously throughout the 120 day life-span of the erythrocyte, between HbAo and glucose. It has been shown to represent the time-averaged blood glucose concentration of the preceeding 2 month period, and is independant of day to day fluctuations in the blood glucose concentration. HbA1c therefore acts as a biochemical marker and permits clinicans, by one test, to judge the quality of the diabetic control, in their patients.
糖化血红蛋白(HbA1c)是血红蛋白A0(HbA0)与葡萄糖之间缓慢且几乎不可逆反应的产物,该反应在红细胞120天的生命周期中持续发生。研究表明,它代表了前两个月期间的平均血糖浓度,且不受血糖浓度每日波动的影响。因此,糖化血红蛋白作为一种生化标志物,使临床医生通过一项检测就能判断患者糖尿病的控制情况。