Schröter W, Jentsch E, Stumpf B, Kubel R, Turner-Heckmann E, Gahr M
Helv Paediatr Acta. 1978 Dec;33(6):535-42.
Patients with juvenile diabetes mellitus were studied over a period of six months. During this time their metabolic control was classified and the relation between the blood concentration of the glycosylated hemoglobins Hb A1a + b + c and the degree of diabetic control was established. 12 out of 37 diabetic children were under good control, whereas 6 patients were poorly controlled. Well controlled children had low concentrations of glycosylated hemoglobins, within the range of non-diabetic subjects. Those under poor control showed an almost twofold increase of the concentration of these minor hemoglobins. Hb A1a + b + c levels of 8 newly diagnosed diabetics were also extremely elevated. Since the hemoglobin-sugar linkage is irreversible, these components remains much longer elevated than the blood glucose itself. It is concluded that the determination of Hb A1a + b + c levels is a valuable tool for the evaluation of the efficiency of diabetic therapy in addition to blood and urinary glucose measurements.
对青少年糖尿病患者进行了为期六个月的研究。在此期间，对他们的代谢控制情况进行了分类，并确定了糖化血红蛋白Hb A1a + b + c的血浓度与糖尿病控制程度之间的关系。37名糖尿病儿童中有12名控制良好，而6名患者控制不佳。控制良好的儿童糖化血红蛋白浓度较低，在非糖尿病受试者的范围内。控制不佳的儿童这些次要血红蛋白的浓度几乎增加了一倍。8名新诊断糖尿病患者的Hb A1a + b + c水平也极高。由于血红蛋白与糖的连接是不可逆的，这些成分升高的时间比血糖本身长得多。结论是，除了测量血糖和尿糖外，测定Hb A1a + b + c水平是评估糖尿病治疗效果的一个有价值的工具。
