大鼠生长激素基因：间隔序列分隔mRNA区域。
Rat growth hormone gene: intervening sequences separate the mRNA regions.
作者信息
Soreq H, Harpold M, Evans R, Darnell J E, Bancroft F C
出版信息
Nucleic Acids Res. 1979 Jun 11;6(7):2471-82. doi: 10.1093/nar/6.7.2471.
Abstract
Rat genomic DNA was digested with various restriction endonucleases, separated by gel electrophoresis and hybridized to 125 I-labeled mRNA for the precursor protein to growth hormone. Restriction sites were found within the genomic DNA that were not found in the previously reported DNA sequence corresponding to the mRNA (19). It appears that the gene for growth hormone contains intervening sequences separating the DNA regions that specify mRNA sequences.
摘要
用各种限制性内切酶消化大鼠基因组DNA，通过凝胶电泳分离，然后与生长激素前体蛋白的125I标记的mRNA杂交。在基因组DNA中发现了一些限制性酶切位点，而在先前报道的与该mRNA相对应的DNA序列（19）中未发现这些位点。看来生长激素基因含有间隔序列，这些间隔序列将指定mRNA序列的DNA区域分隔开。
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