隐品碱抗性：酿酒酵母中40S核糖体组分的基因座
Cryptopleurine resistance: genetic locus for a 40S ribosomal component in Saccharomyces cerevisiae.
作者信息
Grant P, Sánchez L, Jiménez A
出版信息
J Bacteriol. 1974 Dec;120(3):1308-14. doi: 10.1128/jb.120.3.1308-1314.1974.
Abstract
Mutants resistant to the phenanthrene alkaloids tylophorine, tylocrebrine, and cryptopleurine have been isolated from the yeast Saccharomyces cerevisiae. A single recessive nuclear gene was responsible for resistance. This resistance locus, cry, was closely linked to the mating locus (2.2 centimorgans). The resistance was ribosomal and was due to an altered 40S ribosomal subunit. The mode of action of these drugs has been examined, and they appear to inhibit the translocation phase of protein synthesis.
摘要
已从酿酒酵母中分离出对菲生物碱娃儿藤碱、 tylocrebrine和隐肋娃儿藤碱具有抗性的突变体。单一隐性核基因导致抗性。这个抗性位点cry与交配位点紧密连锁（2.2厘摩）。抗性是核糖体抗性，是由于40S核糖体亚基发生改变所致。已经研究了这些药物的作用模式，它们似乎抑制蛋白质合成的转位阶段。
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