酵母中抗隐品碱突变体核糖体的修饰
Modification of ribosomes in cryptopleurine-resistant mutants of yeast.
作者信息
Skogerson L, McLaughlin C, Wakatama E
出版信息
J Bacteriol. 1973 Nov;116(2):818-22. doi: 10.1128/jb.116.2.818-822.1973.
Abstract
Cryptopleurine-resistant mutants of Saccharomyces cerevisiae were isolated. A single, recessive nuclear gene, very closely linked to the mating locus (2.1 centimorgans), is responsible for resistance. Ribosomes from the mutants were found to be resistant to cryptopleurine when analyzed by poly(U)-directed polyphenylalanine synthesis. Analysis of the distribution of ribosomes between monosomes and polysomes in sensitive cells exposed to cryptopleurine suggests that some step is inhibited during the elongation phase of protein synthesis.
摘要
分离出了酿酒酵母的抗隐品碱突变体。一个与交配位点紧密连锁（2.1厘摩）的单一隐性核基因负责这种抗性。当通过聚（U）指导的多聚苯丙氨酸合成进行分析时，发现突变体的核糖体对隐品碱具有抗性。对暴露于隐品碱的敏感细胞中核糖体在单体和多聚体之间的分布分析表明，蛋白质合成的延伸阶段的某个步骤受到了抑制。
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