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酵母中抗隐品碱突变体核糖体的修饰

Modification of ribosomes in cryptopleurine-resistant mutants of yeast.

作者信息

Skogerson L, McLaughlin C, Wakatama E

出版信息

J Bacteriol. 1973 Nov;116(2):818-22. doi: 10.1128/jb.116.2.818-822.1973.

DOI:10.1128/jb.116.2.818-822.1973
PMID:4583252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC285451/
Abstract

Cryptopleurine-resistant mutants of Saccharomyces cerevisiae were isolated. A single, recessive nuclear gene, very closely linked to the mating locus (2.1 centimorgans), is responsible for resistance. Ribosomes from the mutants were found to be resistant to cryptopleurine when analyzed by poly(U)-directed polyphenylalanine synthesis. Analysis of the distribution of ribosomes between monosomes and polysomes in sensitive cells exposed to cryptopleurine suggests that some step is inhibited during the elongation phase of protein synthesis.

摘要

分离出了酿酒酵母的抗隐品碱突变体。一个与交配位点紧密连锁（2.1厘摩）的单一隐性核基因负责这种抗性。当通过聚（U）指导的多聚苯丙氨酸合成进行分析时，发现突变体的核糖体对隐品碱具有抗性。对暴露于隐品碱的敏感细胞中核糖体在单体和多聚体之间的分布分析表明，蛋白质合成的延伸阶段的某个步骤受到了抑制。

相似文献

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Modification of ribosomes in cryptopleurine-resistant mutants of yeast.酵母中抗隐品碱突变体核糖体的修饰
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Genetics and biochemistry of cryptopleurine resistance in the yeast Saccharomyces cerevisiae.酿酒酵母中隐品碱抗性的遗传学与生物化学
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Trichodermin resistance--mutation affecting eukaryotic ribosomes.抗木霉菌素——影响真核生物核糖体的突变
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引用本文的文献

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The monocistronic nature of ribosomal protein genes in yeast.酵母核糖体蛋白基因的单顺反子特性。
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Interconversion of Yeast Mating Types II. Restoration of Mating Ability to Sterile Mutants in Homothallic and Heterothallic Strains.酵母交配型 II 的相互转换。同宗和异宗交配菌株中不育突变体交配能力的恢复。
Genetics. 1977 Mar;85(3):373-93. doi: 10.1093/genetics/85.3.373b.
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Healing of mat mutations and control of mating type interconversion by the mating type locus in Saccharomyces cerevisiae.酿酒酵母中交配型基因座对mat突变的修复及交配型相互转换的控制
Proc Natl Acad Sci U S A. 1979 Jul;76(7):3425-9. doi: 10.1073/pnas.76.7.3425.
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Control of yeast cell types by mobile genes: a test.通过移动基因控制酵母细胞类型：一项测试
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5264-8. doi: 10.1073/pnas.76.10.5264.
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Molecular genetics of cryptopleurine resistance in Saccharomyces cerevisiae: expression of a ribosomal protein gene family.酿酒酵母中隐品碱抗性的分子遗传学：核糖体蛋白基因家族的表达
Genetics. 1993 Nov;135(3):719-30. doi: 10.1093/genetics/135.3.719.
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The trans action of HMRa in mating type interconversion.HMRa在交配型相互转换中的作用。 （注：原句中“trans action”可能有误，推测可能是“action”，这里按推测的正确内容翻译，供你参考，若原词无误请根据实际情况调整）
Mol Gen Genet. 1980;180(1):99-105. doi: 10.1007/BF00267357.

本文引用的文献

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Studies on the Biochemical Genetics of Yeast.酵母的生化遗传学研究
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Genetic mapping in Saccharomyces.酿酒酵母中的基因图谱
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Inhibitors of protein synthesis by ribosomes of the 80-S type.80-S型核糖体蛋白质合成抑制剂。
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7
Formation of a ternary complex between yeast aminoacyl-tRNA binding factor, GTP, and aminoacyl-tRNA.酵母氨酰-tRNA结合因子、GTP和氨酰-tRNA之间三元复合物的形成。
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Differentiation in vitro by phenanthrene alkaloids of yeast mitochondrial protein synthesis from ribosomal systems of both yeast and bacteria.
Biochem Biophys Res Commun. 1968 Nov 8;33(3):368-73. doi: 10.1016/0006-291x(68)90579-2.
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Inhibition of protein synthesis in Ehrlich ascites-tumour cells by the phenanthrene alkaloids tylophorine, tylocrebrine and cryptopleurine.
Biochem Biophys Res Commun. 1968 Apr 5;31(1):104-9. doi: 10.1016/0006-291x(68)90037-5.
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Mode of action of tylocrebrine: effects on protein and nucleic acid synthesis.曲麦角碱的作用方式：对蛋白质和核酸合成的影响。
Mol Pharmacol. 1972 Sep;8(5):538-50.