Hiesche K D, Révész L
Pathol Res Pract. 1979 May;164(2):157-66. doi: 10.1016/S0344-0338(79)80020-5.
The effect of cortisone treatment on the ability of bone marrow cells to repopulate X-irradiated thymus was investigated. In one experimental series, groups of mice were treated first with cortisone and then irradiated with or without bone marrow protection. Mice treated with either cortisone or radiation alone served as controls. During an initial, bone marrow independent phase of thymus regeneration, cortisone had a stronger inhibitory effect on the cellular regeneration of the organ than irradiation. On the other hand, during a subsequent bone marrow dependent phase, thymus regeneration was impaired by radiation exposure but not by cortisone treatment. In another experimental series, irradiated mice were transplanted with bone marrow cells in different numbers from syngeneic donors which had either been treated with cortisone or were left untreated. Twenty days later the cell number was consistently larger in the thymus of animals which has been transplanted with cortisone treated bone marrow than in the animals transplanted with untreated bone marrow. It is concluded that the thymus lymphocyte precursors in the bone marrow and the early precursors of thymocytes in the thymus differ with regard to their sensitivity to cortisone and radiation and, therefore, may represent two distinct cell types.
研究了可的松治疗对骨髓细胞重新填充受X射线照射的胸腺能力的影响。在一个实验系列中，将几组小鼠先给予可的松治疗，然后进行有或无骨髓保护的照射。单独给予可的松或辐射治疗的小鼠作为对照。在胸腺再生的初始骨髓非依赖阶段，可的松对该器官细胞再生的抑制作用比辐射更强。另一方面，在随后的骨髓依赖阶段，胸腺再生因辐射暴露而受损，但不受可的松治疗的影响。在另一个实验系列中，将受照射的小鼠移植来自同基因供体的不同数量的骨髓细胞，这些供体要么接受了可的松治疗，要么未接受治疗。20天后，移植了经可的松处理的骨髓的动物胸腺中的细胞数量始终比移植未处理骨髓的动物胸腺中的细胞数量多。得出的结论是，骨髓中的胸腺淋巴细胞前体和胸腺中的胸腺细胞早期前体对可的松和辐射的敏感性不同，因此可能代表两种不同的细胞类型。
