Loddenkemper R, Eichhorn B, Walter M, Brandt H J
Prax Klin Pneumol. 1979 Apr;33 Suppl 1:673-9.
In 42 patients with obstructive airways diseases the behavior of the mixing index (delta argon %/1 during phase III of the argon-volume diagram) was studied after beta2 stimulation or after provocation by acetylcholine. Changes in airways resistance resp. conductance (GAW), FEV1.0 and residual volume (RV) were also determined for comparison. In an inhomogeneous subgroup with obstructive airways disease of various aetiology the mixing index (MI) and FEV1.0 indicated changes in the airways system with about equal frequency. Distinct discrepancies between the two tests, observed in a few cases, suggest that the two methods register different pathophysiological reactions. These differences could be confirmed statistically in a more homogeneous subgroup with extrinsic bronchial asthma. A correlation could be established between MI and RV on the one hand and between FEV1.0 or GAW and RV on the other hand. The results indicate that the mixing index as a test of distribution of ventilation reflects mainly the reactions of the small airways. Its use offers the possibility of a more differentiated pharmacodynamic evaluation.
在42例阻塞性气道疾病患者中，研究了β2激动剂刺激后或乙酰胆碱激发后混合指数（氩气容量图第三阶段期间的δ氩气%/1）的变化情况。同时测定气道阻力和传导率（GAW）、第一秒用力呼气容积（FEV1.0）和残气量（RV）的变化以作比较。在病因各异的阻塞性气道疾病不均匀亚组中，混合指数（MI）和FEV1.0显示气道系统变化的频率大致相同。少数病例中观察到两种测试之间存在明显差异，这表明两种方法记录的是不同的病理生理反应。在更均匀的外源性支气管哮喘亚组中，这些差异可以通过统计学方法得到证实。一方面，MI与RV之间可建立相关性；另一方面，FEV1.0或GAW与RV之间也可建立相关性。结果表明，作为通气分布测试的混合指数主要反映小气道的反应。其应用为更具差异化的药效学评估提供了可能。
