[Changes in lipid metabolism in pregnant white rats and their fetuses in inhalational exposure to carbon disulfide].

It is known from the literature that carbon bisulphide affects lipid metabolism, but observations in this field are quite controversial. In the present work the authors studied the influence of carbon bisulphide on some parameters of lipid metabolism in pregnant albino rats, following inhalatory exposure to carbon bisulphide concentrations of 50, 100 and 200 mg/m3, 8 hours daily throughout the whole gestation period. The lipid metabolism changes were followed up both in two subsequent generations. The offsprings were examined at birth and after they had reached sexual maturity, at the end of gestation. Part of the animals of the basic generation were subjected to repeated carbon bisulphide treatment in the same concentrations. The following parameters were studied: total lipids, triglycerides, phospholipids, cholesterol and free fatty acids in the liver. Correlation dependencies were found between exposure carbon bisulphide concentrations and the parameters of lipid metabolism. The degree and nature of the changes depended on the concentration and type of exposure (antenatal, postnatal and combined). A distinct rise in free fatty acid levels was associated with a mild decrease in the triglyceride and phospholipid content.