Balabaeva L, Tabakova S
Probl Khig. 1979;4:92-100.
It is known from the literature that carbon bisulphide affects lipid metabolism, but observations in this field are quite controversial. In the present work the authors studied the influence of carbon bisulphide on some parameters of lipid metabolism in pregnant albino rats, following inhalatory exposure to carbon bisulphide concentrations of 50, 100 and 200 mg/m3, 8 hours daily throughout the whole gestation period. The lipid metabolism changes were followed up both in two subsequent generations. The offsprings were examined at birth and after they had reached sexual maturity, at the end of gestation. Part of the animals of the basic generation were subjected to repeated carbon bisulphide treatment in the same concentrations. The following parameters were studied: total lipids, triglycerides, phospholipids, cholesterol and free fatty acids in the liver. Correlation dependencies were found between exposure carbon bisulphide concentrations and the parameters of lipid metabolism. The degree and nature of the changes depended on the concentration and type of exposure (antenatal, postnatal and combined). A distinct rise in free fatty acid levels was associated with a mild decrease in the triglyceride and phospholipid content.
从文献中可知，二硫化碳会影响脂质代谢，但该领域的观察结果颇具争议。在本研究中，作者对妊娠白化大鼠在整个妊娠期每天吸入浓度为50、100和200 mg/m³的二硫化碳8小时后，研究了二硫化碳对脂质代谢某些参数的影响。脂质代谢变化在随后的两代中都进行了跟踪。子代在出生时以及妊娠末期达到性成熟后进行了检查。基础代的部分动物以相同浓度接受了二硫化碳的重复处理。研究了以下参数：肝脏中的总脂质、甘油三酯、磷脂、胆固醇和游离脂肪酸。发现二硫化碳暴露浓度与脂质代谢参数之间存在相关性。变化的程度和性质取决于暴露的浓度和类型（产前、产后和联合暴露）。游离脂肪酸水平的明显升高与甘油三酯和磷脂含量的轻度降低有关。
