Petrova S
Vopr Pitan. 1985 Sep-Oct(5):43-5.
The author studied the influence of pyridoxine (8 mg/kg bw) on upset lipid metabolism in rats exposed to carbon disulfide (30 mg/m3) inhalation over 90 days. The content of total lipids, total esterified and free cholesterol, free fatty acids, phospholipids, triglycerides and beta-lipoproteins was measured in serum on days 15, 30 and 90 since exposure. Carbon disulfide alone caused a reduction in the level of some lipid groups on day 15, whereas on days 30 and 90 it provokes an elevation of the content of total fats and all lipid groups under study. Administration of pyridoxine alone brought about a decrease in lipid characteristics. The combined use of the vitamin and carbon disulfide made these characteristics return to normal. Pyridoxine is a possible active factor in the prophylaxis of atherosclerotic lesions in carbon disulfide poisoning.
作者研究了吡哆醇（8毫克/千克体重）对吸入二硫化碳（30毫克/立方米）90天的大鼠脂质代谢紊乱的影响。在暴露后的第15天、30天和90天测定血清中总脂质、总酯化胆固醇和游离胆固醇、游离脂肪酸、磷脂、甘油三酯和β-脂蛋白的含量。单独的二硫化碳在第15天导致一些脂质组水平降低，而在第30天和90天则引起总脂肪和所有研究脂质组含量升高。单独给予吡哆醇导致脂质特征下降。维生素和二硫化碳联合使用使这些特征恢复正常。吡哆醇可能是预防二硫化碳中毒时动脉粥样硬化病变的活性因子。
