[Action of pyridoxine on lipid metabolism in carbon disulfide-poisoned rats].

The author studied the influence of pyridoxine (8 mg/kg bw) on upset lipid metabolism in rats exposed to carbon disulfide (30 mg/m3) inhalation over 90 days. The content of total lipids, total esterified and free cholesterol, free fatty acids, phospholipids, triglycerides and beta-lipoproteins was measured in serum on days 15, 30 and 90 since exposure. Carbon disulfide alone caused a reduction in the level of some lipid groups on day 15, whereas on days 30 and 90 it provokes an elevation of the content of total fats and all lipid groups under study. Administration of pyridoxine alone brought about a decrease in lipid characteristics. The combined use of the vitamin and carbon disulfide made these characteristics return to normal. Pyridoxine is a possible active factor in the prophylaxis of atherosclerotic lesions in carbon disulfide poisoning.