D'Alessio G, Doskocil J, Libonati M
Biochem J. 1974 Jul;141(1):317-20. doi: 10.1042/bj1410317.
The hypothesis that both active sites of dimeric ribonuclease A have to be simultaneously available in order to make the enzyme able to degrade double-stranded RNA is tested with purified hybrid dimers of ribonuclease A and its carboxymethylated derivative. The results obtained support the hypothesis.
为了使二聚体核糖核酸酶A能够降解双链RNA,其两个活性位点必须同时可用,这一假设通过核糖核酸酶A及其羧甲基化衍生物的纯化杂交二聚体进行了检验。所得结果支持该假设。