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天然及选择性烷基化核糖核酸酶A的二聚体杂合体对双链核糖核酸的作用。

Action of dimeric hybrids of native and selectively alkylated ribonuclease A on double-stranded ribonucleic acid.

作者信息

D'Alessio G, Doskocil J, Libonati M

出版信息

Biochem J. 1974 Jul;141(1):317-20. doi: 10.1042/bj1410317.

Abstract

The hypothesis that both active sites of dimeric ribonuclease A have to be simultaneously available in order to make the enzyme able to degrade double-stranded RNA is tested with purified hybrid dimers of ribonuclease A and its carboxymethylated derivative. The results obtained support the hypothesis.

摘要

为了使二聚体核糖核酸酶A能够降解双链RNA,其两个活性位点必须同时可用,这一假设通过核糖核酸酶A及其羧甲基化衍生物的纯化杂交二聚体进行了检验。所得结果支持该假设。

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本文引用的文献

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Action of dimeric ribonucleases on double-stranded RNA.二聚体核糖核酸酶对双链RNA的作用。
FEBS Lett. 1972 Aug 15;24(3):355-358. doi: 10.1016/0014-5793(72)80390-9.
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Degradation of poly A and double-stranded RNA by aggregates of pancreatic ribonuclease.
Biochim Biophys Acta. 1971 Jan 28;228(2):440-5. doi: 10.1016/0005-2787(71)90049-9.
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A nuclease from animal serum which hydrolyzes double-stranded RNA.一种来自动物血清的核酸酶,可水解双链RNA。
Biochem Biophys Res Commun. 1970 Nov 9;41(3):608-14. doi: 10.1016/0006-291x(70)90056-2.

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