大脑中生物胺代谢的模拟
Simulation of biogenic amine metabolism in the brain.
作者信息
Turner A J, Illingworth J A, Tipton K F
出版信息
Biochem J. 1974 Nov;144(2):353-60. doi: 10.1042/bj1440353.
The metabolism of a number of biogenic amines has been simulated by using data obtained from studies of the individual enzymes from pig brain. It is shown that beta-hydroxylated amines such as noradrenaline and octopamine are metabolized primarily to the alcoholic metabolite whereas amines lacking this group [e.g. dopamine (3,4-dihydroxyphenethylamine) and 5-hydroxytryptamine] are metabolized at low concentrations to give the corresponding acid. Increase in the amine concentration results in an increase in the proportion of the alcoholic metabolite formed and this may in part account for the effects of the drug reserpine on amine metabolism. The effects of disulfiram (Antabuse) and ethanol (acting through its metabolite acetaldehyde) on amine metabolism may be understood in terms of this simulated model. It is shown that drugs that affect this system also cause alterations in the steady-state concentrations of the intermediate aldehydes and the possible implications of this are discussed.
通过使用从猪脑单个酶的研究中获得的数据，对多种生物胺的代谢进行了模拟。结果表明，β-羟基化胺如去甲肾上腺素和章鱼胺主要代谢为醇类代谢物，而缺乏该基团的胺[如多巴胺（3,4-二羟基苯乙胺）和5-羟色胺]在低浓度下代谢生成相应的酸。胺浓度的增加导致形成的醇类代谢物比例增加，这可能部分解释了药物利血平对胺代谢的影响。根据这个模拟模型，可以理解双硫仑（安塔布司）和乙醇（通过其代谢物乙醛起作用）对胺代谢的影响。结果表明，影响该系统的药物也会导致中间醛稳态浓度的改变，并讨论了其可能的影响。
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