线粒体的生物发生。酵母线粒体和微粒体部分体外磷脂合成。
Biogenesis of mitchondria. Phospholipid synthesis in vitro by yeast mitochondrial and microsomal fractions.
作者信息
Cobon G S, Crowfoot P D, Linnane A W
出版信息
Biochem J. 1974 Nov;144(2):265-75. doi: 10.1042/bj1440265.
Abstract
The ability in vitro of yeast mitochondrial and microsomal fractions to synthesize lipid de novo was measured. The major phospholipids synthesized from sn-[2-(3)H]glycerol 3-phosphate by the two microsomal fractions were phosphatidylserine, phosphatidylinositol and phosphatidic acid. The mitochondrial fraction, which had a higher specific activity for total glycerolipid synthesis, synthesized phosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine and phosphatidic acid, together with smaller amounts of neutral lipids and diphosphatidylglycerol. Phosphatidylcholine synthesis from both S-adenosyl[Me-(14)C]methionine and CDP-[Me-(14)C]choline appeared to be localized in the microsomal fraction.
摘要
对酵母线粒体和微粒体组分在体外从头合成脂质的能力进行了测定。两个微粒体组分由sn-[2-(3)H]甘油3-磷酸合成的主要磷脂是磷脂酰丝氨酸、磷脂酰肌醇和磷脂酸。线粒体组分对总甘油脂合成具有较高的比活性，它合成了磷脂酰甘油、磷脂酰乙醇胺、磷脂酰肌醇、磷脂酰丝氨酸和磷脂酸，同时还合成了少量的中性脂质和二磷脂酰甘油。由S-腺苷[Me-(14)C]甲硫氨酸和CDP-[Me-(14)C]胆碱合成磷脂酰胆碱的过程似乎定位于微粒体组分中。
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