Arbex S T, Neder A C, de Mattos Filho T R, Ramos A O
Rev Bras Pesqui Med Biol. 1979 Apr;12(1):1-6.
The purpose of the present investigation was to determine the action of prilocaine as hypotensive ocular agent. Prilocaine in doses of 2.5 mg/kg, 5 mg/kg and 10 mg/kg was administered intravenously in dogs anesthetized with sodium pentobarbital (30 mg/kg). The experiments show that prilocaine when used i.v. in doses of 2.5 mg/kg and 5 mg/kg causes ocular hypotension in dogs, whereas doses of 10 mg/kg i.v. produce this effect only when artificial respiration is employed, thus preventing the increase of the pCO2 in the blood.
本研究的目的是确定丙胺卡因作为降眼压药物的作用。将剂量为2.5mg/kg、5mg/kg和10mg/kg的丙胺卡因静脉注射给用戊巴比妥钠（30mg/kg）麻醉的犬。实验表明，静脉注射2.5mg/kg和5mg/kg剂量的丙胺卡因可使犬眼压降低，而静脉注射10mg/kg剂量时，仅在采用人工呼吸从而防止血液中pCO2升高的情况下才产生这种效果。
