Oliveira-Filho R M, Valle L B, Camara S A, Peres C A
Acta Physiol Lat Am. 1978;28(2-3):121-6.
The intravenous administration of BaCl2 (2 mg/kg) in dogs anesthetized with nembutal determined sharp rise of arterial blood pressure, bradycardia, enlargement of PR interval and QRS complex, and bigeminated ventricular extrasystoles. Prilocaine (20 mg/kg iv) caused only slight fall of arterial blood pressure, mild bradycardia, enlargement of PR interval and QRS complex. When the drugs were administered simultaneously, prilocaine effectively antagonized pressor and heart rhythm alterations induced by barium. However, bradycardia and PR interval enlargement were even more severe, thus indicating a synergistic action of the drugs. It is shown that the statistical analysis based on a multiple regression model is quite suitable for this kind of experimental design.
给用戊巴比妥麻醉的狗静脉注射氯化钡（2毫克/千克），可使动脉血压急剧升高、出现心动过缓、PR间期和QRS波群增宽以及室性早搏二联律。静脉注射丙胺卡因（20毫克/千克）仅引起动脉血压轻度下降、轻度心动过缓、PR间期和QRS波群增宽。当同时给予这两种药物时，丙胺卡因可有效对抗钡引起的升压和心律改变。然而，心动过缓和PR间期增宽更为严重，表明这两种药物具有协同作用。结果表明，基于多元回归模型的统计分析非常适合这种实验设计。
