Poli G, Canuto R A, Gravela E
Res Commun Chem Pathol Pharmacol. 1979 Feb;23(2):407-10.
Cytochrome P-450 content and dimethylnitrosamine demethylase activity were determined in the liver of male rats fed a polyunsaturated fatty acid deficient diet. The damaging activity of dimethylnitrosamine (DMN) on liver polyribosomes of control and treated rats was estimated. The reduction of DMN demethylase activity did not protect against polysome derangement due to DMN. These data are consistent with the hypothesis that metabolic pathways, other than the P-450 dependent one, are involved in the DMN bioactivation.
测定了喂食多不饱和脂肪酸缺乏饮食的雄性大鼠肝脏中的细胞色素P-450含量和二甲基亚硝胺脱甲基酶活性。评估了二甲基亚硝胺（DMN）对对照大鼠和处理大鼠肝脏多核糖体的破坏活性。DMN脱甲基酶活性的降低并不能防止由于DMN导致的多核糖体紊乱。这些数据与以下假设一致，即除了依赖细胞色素P-450的代谢途径外，其他代谢途径也参与了DMN的生物活化。
