风疹病毒诱导的荧光抗体在疫苗接种者和恢复期个体中的比较。

Serafini A, Cole G C, Brackett R G

Appl Microbiol. 1972 Jan;23(1):66-71. doi: 10.1128/am.23.1.66-71.1972.

Specific rubella antibody detectable by indirect immunofluorescence developed in response to immunization with attenuated rubella vaccine, HPV-77, DK-12. Fluorescent antibody (FA) was found when vaccinee sera were reacted with antigens synthesized in three different acutely infected continuous cell lines: BHK-21, LLCMK-2, and RK-13. FA titers were high, and they correlated with antibody titers obtained by hemagglutination-inhibition tests. Levels of FA in vaccinated individuals were slightly lower than those found in persons recovered from natural rubella infections. Rubella FA persists a long time in convalescent individuals and appears to be maintained for at least 19 months in vaccinees.

通过间接免疫荧光法可检测到的特异性风疹抗体是在接种减毒风疹疫苗HPV - 77、DK - 12后产生的。当接种疫苗者的血清与在三种不同的急性感染连续细胞系（BHK - 21、LLCMK - 2和RK - 13）中合成的抗原反应时，发现了荧光抗体（FA）。FA滴度很高，并且与通过血凝抑制试验获得的抗体滴度相关。接种疫苗个体中的FA水平略低于从自然风疹感染中康复的人。风疹FA在恢复期个体中持续很长时间，并且在接种疫苗者中似乎至少维持19个月。