黑腹果蝇中的温度敏感突变。IX. 常染色体上的显性冷敏感致死基因。
Temperature-sensitive mutations in Drosophila melanogaster. IX. Dominant cold-sensitive lethals on the autosomes.
作者信息
Rosenbluth R, Ezell D, Suzuki D T
出版信息
Genetics. 1972 Jan;70(1):75-86. doi: 10.1093/genetics/70.1.75.
Abstract
Ethyl methanesulfonate-treated autosomes were screened for the presence of dominant cold-sensitive (DCS) lethal mutations in Drosophila melanogaster. None was found among 6,552 treated and 168 untreated third chromosomes. Twenty-three DCS-L chromosomes which caused death at 17 degrees C but survived at 22 degrees C and 29 degrees C were recovered from 5,046 mutagenized chromosome 2's.-The DCS-L mutations all mapped around dp and appeared to be functionally allelic. Lethality of heterozygotes for most of the DCS-L's occurred over a prolonged interval from the embryonic through the larval instars. Prolonged incubation at 17 degrees C did not demonstrate any maternal effect on zygotic survival.
摘要
对经甲磺酸乙酯处理的常染色体进行筛选，以检测黑腹果蝇中显性冷敏感（DCS）致死突变的存在。在6552条经处理的和168条未经处理的第三染色体中均未发现此类突变。从5046条经诱变的第二染色体中获得了23条DCS-L染色体，这些染色体在17℃时致死，但在22℃和29℃时存活。-DCS-L突变均定位在dp附近，且似乎在功能上是等位基因。大多数DCS-L杂合子的致死性发生在从胚胎期到幼虫龄期的较长时间段内。在17℃下长时间孵育未显示对合子存活有任何母体效应。
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