长期接受治疗的患者心肌和骨骼肌中的地高辛浓度。
Myocardial and skeletal muscle concentrations of digoxin in patients on long-term therapy.
作者信息
Coltart J, Howard M, Chamberlain D
出版信息
Br Med J. 1972 May 6;2(5809):318-9. doi: 10.1136/bmj.2.5809.318.
Abstract
The digoxin content was measured in samples of left ventricular papillary muscle, skeletal muscle, and plasma obtained during mitral valve replacement from eight patients on maintenance treatment with the drug. The content in papillary muscle ranged from 15.5 to 132 ng/g (mean 77.7) and in skeletal muscle from 7.5 to 23 ng/g (mean 11.3). The ratio of myocardial digoxin concentration to plasma concentration varied between patients from 39:1 to 155:1. No simple relationship exists between plasma levels of digoxin and its concentration in the heart muscle, but total myocardial concentration may not accurately reflect therapeutic activity.
摘要
对8例正在接受地高辛维持治疗的患者，在二尖瓣置换手术期间采集左心室乳头肌、骨骼肌和血浆样本，测量其中地高辛含量。乳头肌中的含量为15.5至132纳克/克（平均77.7），骨骼肌中的含量为7.5至23纳克/克（平均11.3）。患者之间心肌地高辛浓度与血浆浓度之比在39:1至155:1之间。地高辛的血浆水平与其在心肌中的浓度之间不存在简单的关系，但心肌总浓度可能无法准确反映治疗活性。
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