宫内感染与脐带免疫球蛋白M。一、正常新生儿免疫球蛋白M检测方法及水平分析

Intrauterine infection and cord immunoglobulin M. I. Analysis of methods of assay and levels of immunoglobulin M in normal newborns.

作者信息

Dent P B, Finkel A, Iturzaeta N, Gent M, Bienenstock J

出版信息

Can Med Assoc J. 1972 Apr 22;106(8):889-93.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1940589/

Abstract

An analysis of methods of assay and levels of immunoglobulin M in the cord serum of 100 normal newborn infants is reported. The geometric mean level of cord IgM was found to be 9.8 mg.%. The 95th percentile value was 19.6 mg.%. IgM levels on day one were not significantly different from cord levels, while by day five a significant increase had occurred (geometric mean 13.6 mg.%). IgA was present in only 3/100 cord sera (in levels above 6.0 mg.%). Any increment of day five IgM over cord levels greater than threefold is thought to be abnormal and this parameter will be further evaluated as an index of neonatal sepsis. Use of locally produced reagents in the IgM assay was found to be more accurate and inexpensive than the commercially available reagents.

摘要

报告了对100名正常新生儿脐带血清中免疫球蛋白M的检测方法及水平的分析。发现脐带IgM的几何平均水平为9.8mg.%。第95百分位数为19.6mg.%。出生第一天的IgM水平与脐带水平无显著差异，而到第五天则出现了显著升高（几何平均为13.6mg.%）。100份脐带血清中仅有3份存在IgA（水平高于6.0mg.%）。出生后第五天IgM水平相对于脐带水平升高超过三倍被认为是异常的，该参数将作为新生儿败血症的指标进行进一步评估。发现在IgM检测中使用本地生产的试剂比市售试剂更准确且更便宜。

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本文引用的文献

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