Ohanian S H, Borsos T
J Immunol. 1975 Jan;114(1 Pt 1):161-4.
Antigenic similarity between cell-bound human and guinea pig C4 was detected with antisera specific for each of these molecules. No cross-reaction could be detected between C4 of normal guinea pig or human sera or after treatment of the sera with antigen-antibody C1 complexes. The cross-reactivity between cell-bound human and guinea pig C4 may reflect conformational changes in the C4 molecule as a result of binding of the cell surface.
利用针对人源和豚鼠源这些分子各自的抗血清，检测了细胞结合的人源和豚鼠源C4之间的抗原相似性。在正常豚鼠或人血清的C4之间，或者在用抗原-抗体C1复合物处理血清后，均未检测到交叉反应。细胞结合的人源和豚鼠源C4之间的交叉反应性可能反映了由于细胞表面结合导致的C4分子构象变化。
