豚鼠红细胞上对人补体第四成分（C4）的细胞结合形式具有特异性的受体。
Receptors on guinea-pig erythrocytes specific for cell-bound fourth component of human complement (C4).
作者信息
Wilson A B, Prichard-Thomas S, Lachmann P J, Coombs R R
出版信息
Immunology. 1980 Feb;39(2):195-202.
Guinea-pig erythrocytes have receptors for heterologous (human and rabbit) complement activated by the classical pathway on cell surfaces. This was shown in the present study by rosette-forming reactions of guinea-pig erythrocytes and human lymphocytes or sheep erythrocytes pre-treated with antibody and human R3 complement. The binding is temperature-dependent and is enhanced by treating the guinea-pig erythrocytes with neuraminidase. The receptors were shown to be specific for C4 by inhibition tests employing a range of anti-human complement antibodies (including anti-Clq, -Cl inhibitor, -C4, -C2, -C3 and -C3b inactivator). Of these reagents, only anti-C4 inhibited the receptor activity, indicating that the guinea-pig erythrocyte C4-receptors differ from those on lymphocytes, monocytes, polymorphonuclear leucocytes and human erythrocytes which are reported to react with both C3b and C4b. In contrast to the strong affinity observed for heterologous C4, guinea-pig erythrocytes appear to react very weakly, if at all, with homologous C4.
豚鼠红细胞在细胞表面具有通过经典途径激活的异源（人及兔）补体的受体。本研究通过豚鼠红细胞与经抗体和人R3补体预处理的人淋巴细胞或绵羊红细胞的玫瑰花结形成反应证明了这一点。这种结合是温度依赖性的，并且通过用神经氨酸酶处理豚鼠红细胞而增强。通过使用一系列抗人补体抗体（包括抗Clq、抗Cl抑制剂、抗C4、抗C2、抗C3和抗C3b灭活剂）的抑制试验表明，这些受体对C4具有特异性。在这些试剂中，只有抗C4抑制受体活性，这表明豚鼠红细胞C4受体与淋巴细胞、单核细胞、多形核白细胞和人红细胞上的受体不同，据报道后者可与C3b和C4b都发生反应。与观察到的对异源C4的强亲和力相反，豚鼠红细胞似乎与同源C4反应非常微弱，甚至根本不反应。
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