Habel A H, Sandor G S, Conn N K, McCrae W M
Arch Dis Child. 1972 Jun;47(253):401-4. doi: 10.1136/adc.47.253.401.
A series of 100 infants born after prolonged rupture of membranes was studied to evaluate the risk of infection to the infant due to this circumstance alone, and to assess the effect of prophylactic antibiotics in its prevention. Evidence of bacterial colonization at birth was limited to 6 cases and no clinical infection ensued. Neonatal infection was uniformly low but the administration of antibiotics led to clinical candidiasis in 18% and the development of a replacement flora of fungi in the intestinal tract in 70%. It is concluded that the routine administration of prophylactic antibiotics to the infant born in these circumstances is unnecessary and potentially hazardous.
对100例胎膜早破后出生的婴儿进行了一系列研究，以评估仅因这种情况给婴儿带来的感染风险，并评估预防性使用抗生素在预防感染方面的效果。出生时细菌定植的证据仅见于6例，且未发生临床感染。新生儿感染率一直较低，但使用抗生素导致18%的婴儿出现临床念珠菌病，70%的婴儿肠道内出现真菌替代菌群。得出的结论是，对在这些情况下出生的婴儿常规使用预防性抗生素是不必要的，而且可能有危害。
