Matsuda Y, Ikenoue T, Hokanishi H
Department of Obstetrics and Gynecology, Kagoshima Municipal Hospital, Japan.
Gynecol Obstet Invest. 1993;36(2):102-7. doi: 10.1159/000292605.
The purpose of this randomized, prospective study was to evaluate the efficacy of tocolytic and antibiotic therapy in the prolongation of pregnancy and neonatal outcome in the treatment of premature rupture of the membranes without clinical labor. Delivery was delayed for 48 h, 7 days and beyond 35 weeks of gestation in 87, 39 and 18%, respectively, of patients in the treated group (n = 39) compared with 50, 12 and 17% of patients in the nontreated group (n = 42). The incidence of a low Apgar score (< 7 at 5 min), requiring artificial ventilation, and infectious morbidity was more common in the treated group than in the nontreated group (18 vs. 0, 41 vs. 17 and 39 vs. 17%, respectively). There was no significant cost difference in survivors between the treated and nontreated groups, although the mothers in the treated group were significantly more expensive. From these observations, it appears that tocolysis and antibiotics are not effective in PROM cases.
这项随机前瞻性研究的目的是评估在未临产的胎膜早破治疗中，宫缩抑制剂和抗生素治疗在延长孕周及新生儿结局方面的疗效。治疗组（n = 39）中分别有87%、39%和18%的患者分娩延迟了48小时、7天及超过妊娠35周，而未治疗组（n = 42）中这一比例分别为50%、12%和17%。治疗组中5分钟时阿氏评分低（<7分）、需要人工通气以及感染性发病率的发生率比未治疗组更常见（分别为18%对0、41%对17%和39%对17%）。尽管治疗组的母亲费用明显更高，但治疗组和未治疗组幸存者之间的费用没有显著差异。从这些观察结果来看，宫缩抑制和抗生素在胎膜早破病例中似乎无效。
