通过51-铬依地酸的血浆清除率估算肾小球滤过率。
Estimation of glomerular filtration rate from plasma clearance of 51-chromium edetic acid.
作者信息
Chantler C, Barratt T M
出版信息
Arch Dis Child. 1972 Aug;47(254):613-7. doi: 10.1136/adc.47.254.613.
Abstract
The glomerular filtration rate was estimated by a single compartment analysis of the rate of fall of plasma concentration of 51-chromium edetic acid after a single intravenous injection. This slope clearance consistently overestimated the simultaneously determined standard urinary clearance, but could be used to predict the latter with an accuracy of ±9% (95% confidence limits). The coefficient of variation of replicate estimates of the slope clearance in the same individual was 3·9%; thus two estimates of glomerular filtration rate by this technique which differ by 11% have a 95% probability of reflecting a genuine difference. The method requires an intravenous injection and blood samples at 2 and 4 hours; urine samples are not required. It is simple, safe, and precise, and is applicable to children.
摘要
通过对单次静脉注射后51-铬依地酸血浆浓度下降速率进行单室分析来估算肾小球滤过率。这种斜率清除率始终高估了同时测定的标准尿清除率，但可用于预测后者，其准确度为±9%（95%置信限）。同一受试者重复测量斜率清除率的变异系数为3.9%；因此，用该技术得到的两个肾小球滤过率估算值相差11%时，有95%的可能性反映真实差异。该方法需要静脉注射，并在2小时和4小时采集血样；无需采集尿样。它简单、安全且精确，适用于儿童。
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