Anderson L G, Talal N
Clin Exp Immunol. 1972 Feb;10(2):199-221.
Clinical and pathological evidence suggests that a wide spectrum of lymphoproliferation exists in Sjögren's syndrome (SS), from benign disease with lymphoid infiltrates confined to glandular tissue on the one end, to widespread lymphoreticular malignancy on the other. In the middle of the spectrum are patients threatened by extraglandular extension of lymphoproliferation which is not clinically or histologically malignant and which apparently has the potential to regress with appropriate therapy or to progress to frank neoplasia. Illustrative patients are described. Over thirty other case reports associating SS with pseudolymphoma, Waldenstrom's macroglobulinaemia, reticulum cell sarcoma, or other lymphomas appear in the literature. Similar lymphoproliferative processes have been observed in other autoimmune diseases, in certain immune deficiency states, with hydantoin and other anticonvulsant drugs, and in experimental animal models. In SS, as in these other conditions, it seems likely that a combination of genetic, immunologic, and viral or other unknown environmental factors plays a role in pathogenesis.
临床和病理证据表明，干燥综合征（SS）存在广泛的淋巴细胞增殖，一端是局限于腺组织的淋巴细胞浸润的良性疾病，另一端是广泛的淋巴网状恶性肿瘤。处于这个范围中间的是那些受到淋巴细胞增殖腺外扩展威胁的患者，这种增殖在临床或组织学上并非恶性，并且显然有可能通过适当治疗而消退或进展为明显的肿瘤。文中描述了一些具有代表性的患者。文献中还出现了三十多篇将SS与假性淋巴瘤、华氏巨球蛋白血症、网状细胞肉瘤或其他淋巴瘤相关联的病例报告。在其他自身免疫性疾病、某些免疫缺陷状态、使用乙内酰脲和其他抗惊厥药物的情况下以及实验动物模型中，也观察到了类似的淋巴细胞增殖过程。与这些其他情况一样，在SS中，遗传、免疫、病毒或其他未知环境因素的综合作用似乎在发病机制中发挥了作用。
